Non-coding regulatory elements: potential roles in disease and the case of epilepsy – DocWire News

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Neuropathol Appl Neurobiol. 2021 Nov 24. doi: 10.1111/nan.12775. On-line forward of print.


Non-coding DNA (ncDNA) Refers again to the portion of the genome That Does not code for proteins and accounts for The biggest bodily proportion of the human genome. ncDNA consists of sequences That are transcribed into RNA molecules, Similar to ribosomal RNAs (rRNAs), microRNAs (miRNAs), prolonged non-coding RNAs (lncRNAs), and un-transcribed sequences Which have regulatory features, collectively with gene promoters and enhancers. Variation in non-coding areas of the genome have A prolongedtime position in human illness, with rising proof from many areas, collectively with a quantity of cancers, Parkinson’s illness and autism. Here, we consider The choices and features of the regulatory parts That are current Inside the non-coding genome and the position that these areas have in human illness. We then consider The prevailing evaluation in epilepsy and emphasise the potential worth of further exploring non-coding regulatory parts in epilepsy. As properly as, we outline In all probability the Most usually used methods for recognising regulatory parts all by way of the genome, current methodologies for investigating variation and The primary challenges Associated to evaluation Inside The sector of non-coding DNA.

PMID:34820881 | DOI:10.1111/nan.12775


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